Resources

Application Notes

High-Throughput Production of Matrix-Embedded Multicellular Tumour Spheroids by Drop-on-Demand 3D Bioprinting

This application note provides an overview of the creation of breast and prostate multicellular tumour spheroids using RASTRUM™.

Cell Retrieval from RASTRUM™ 3D Bioprinted Hydrogels Enables High-Quality RNA and Protein Extraction

This application note demonstrates how cells encapsulated in RASTRUM™ 3D bioprinted matrices can be easily retrieved from the matrix to enable investigations into gene and protein expression.

Brightfield and Fluorescent Imaging of RASTRUM™ 3D Bioprinted Cell Models

This application note demonstrates the compatibility of imaging methods with 3D cell models created using RASTRUM™.

Printable and Tunable 3D Cell Culture Environments using RASTRUM™ Synthetic ECM Hydrogels

This application note provides an overview of the utility and tunability of RASTRUM™ hydrogel matrix systems.

Drop-on-Demand Printing Technology of the RASTRUM™ 3D Bioprinter

This application note details the key printing features offered by RASTRUM™.

Protocols

Cell Recovery from RASTRUM™ Hydrogel Matrices

This protocol outlines how the enzymatic-based RASTRUM™ Cell Recovery Solution can be used to extract 3D cell models encapsulated in RASTRUM™ hydrogel for use in downstream applications.

In Situ Viability Analysis of RASTRUM™ Bioprinted 3D Cell Models

This protocol provides a method to calculate viability of 3D cell models created with RASTRUM using two dyes for distinguishing live and dead cells via fluorescence microscopy.

In Situ Immunofluorescence Analysis of RASTRUM™ Bioprinted 3D Cell Models

This protocol outlines a method to analyse protein expression via immunofluorescence in 3D cell models created with RASTRUM.

Product Videos

The Revolutionary RASTRUM™ 3D Bioprinter Platform

This short video provides an overview of the RASTRUM 3D Bioprinting Platform from Inventia Life Science. RASTRUM is built for 3D cell biology, accelerating drug discovery and biomedical research with the power of digital bioprinting.

The RASTRUM™ 3D Bioprinter Workflow

This short video demonstrates the typical workflow for generating RASTRUM 3D cell models. RASTRUM is a complete and efficient plug and play platform, requiring minimal user involvement to create complex 3D cell models in a simple way.

Interviews

Interview with Dr Julio Ribeiro - Fast Company World Changing Ideas Award

This short video interview with Dr Julio Ribeiro, co-founder and CEO of Inventia Life Science, speaks about RASTRUM being honoured by Fast Company in the 2020 World Changing Ideas Awards in the Experimental Category.

Podcast with Dr Julio Ribeiro speaking to Mark Bouris in his ‘The Mentor’ Podcast series

This podcast featured in Mark Bouris’s ‘The Mentor’ series will take you on the Inventia Life Science journey - from initial idea to the internationally acclaimed RASTRUM 3D Bioprinter.
**Podcast may not be accessible outside Australia**

Press Releases

"Inventia wins Australia’s Good Design Award of the Year for Rastrum 3D bioprinter"

Click here to read the article by the 3D Printing Media Network.

"This 3D printer produces living cancer cells so scientists can test drugs on the real thing"

Click here to read the article by Fast Company.

"RASTRUM™- the 3D Printer of Living Cells, Honored in Annual Awards by Leading Business Magazine"

Click here to read the article by PRWeb.

"Inventia Life Science Empowers Researchers to Rapidly Scale 3D Cell Culture"

Click here to read the article by 3DPrint.com.

"Associate Professor Kieran Scott: Growing 3D brain cancer organoids – the new frontier in cancer research"

Click here to read the article by CONCERT.

Frequently Asked Questions

Platform FAQs

Click here to download the Frequently Asked Questions related to the RASTRUM™ Platform.

Hydrogel FAQs

Click here to download the Frequently Asked Questions related to RASTRUM™ Hydrogels.

Applications FAQs

Click here to download the Frequently Asked Questions related to RASTRUM™ Applications.

Laboratory Requirements FAQs

Click here to download the Frequently Asked Questions related to RASTRUM™ Laboratory Requirements.

Relevant Literature

Peer-Reviewed Publications

1. Heinrich MA, Liu W, Jimenez A, Yang J, Akpek A, Liu X, Pi Q, Mu X, Hu N, Schiffelers RM, Prakash J, Xie J, Zhang YS. 2019. 3D Bioprinting: from Benches to Translational Applications. Small. 15:1805510 - Link

2. Gudapati H, Dey M, Ozbolat I. 2016. A comprehensive review on droplet-based bioprinting: Past, present and future. Biomaterials. 102:20-42 - Link

3. Holle AW, Young JL, Spatz JP. 2016. In vitro cancer cell-ECM interactions inform in vivo cancer treatment. Advanced Drug Delivery Reviews. 97:270-279 - Link

4. Nguyen EH, Daly WT, Le NNT, Farnoodian M, Belair DG, Schwartz MP, Lebakken CS, Ananiev GE, Saghiri MA, Knudsen TB et al. 2017. Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion. Nature Biomedical Engineering. 1:0096 - Link

5. Antoni D, Burckel H, Josset E, Noel G. 2015. Three-Dimensional Cell Culture: A Breakthrough in Vivo. International Journal of Molecular Sciences. 16(3):5517-5527 - Link

6. Langhans SA. 2018. Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning. Frontiers in Pharmacology. 9:6 - Link