Reproducible tumor micro-environments at scale.
Research in cancer is challenging due to the nature of tumour heterogeneity and the intricate complexity of the tumour microenvironment. The highly variable genetic profiles of individual cancer cells within a single tumour leads to variable treatment responses, limiting the effectiveness of treatments.
Traditional 2D cell culture models, although valuable, frequently fail to accurately replicate the dynamic tumour microenvironment, thereby limiting their effectiveness in predicting the outcomes of anti-cancer therapies.
The absence of physiologically relevant cancer models that can account for this diversity further complicates the development of effective treatments.
Tailored matrix composition
Offers customised matrix composition for a range of tissue types to accurately mimic the tumour microenvironment (TME), enabling recreation of conditions surrounding cancer cells for realistic experimental outcomes.
Tissue stiffness variation
Mimics varying tissue stiffnesses (0.7–4.8 kPa) to study cancer cell responses and interactions with their mechanical microenvironment, and gain insights into tumour progression and metastasis.
Optical clarity
Facilitates high-resolution imaging of cancer cell behaviours and dynamic processes within the TME. This system is engineered for clarity and stability, enabling detailed analysis and long-term observation of cancer progression.
TME replication
Utilises diverse architectures to faithfully recreate the tumour microenvironment and study cancer progression in a physiologically relevant context.
Flexible spatial arrangements
Interrogates relationship between cell phenotype and matrix by studying cells in different environments within the same well, facilitating the discovery of novel anti-cancer strategies.
Dynamic experimental control
Adjusts experimental parameters such as matrix composition and stiffness to enhance the relevance and translatability of experimental findings.
User-friendly interface
Provides an intuitive user experience with no coding required, ensuring accessibility for researchers with varying technical backgrounds.
Efficient workflow
Offers a streamlined workflow and setup process, optimising efficiency and ease of use, allowing researchers to focus more on analysis.
Cell-friendly handling
Accommodates sensitive cell types, including patient-derived cells, induced pluripotent stem cells (iPSCs) and immortalised cells, this system maintains their integrity and physiological relevance throughout experiments while being gentle on cells.
